A 2025 randomized, double-blind, placebo-controlled trial used hydrolysed collagen at exactly this dose — 3,000 mg/day for 180 days — and found statistically significant improvement in WOMAC pain and function scores versus placebo in adults with knee osteoarthritis.
Glucosamine and chondroitin are included at the doses from the landmark NEJM GAIT trial; with clearer benefit concentrated in the moderate-to-severe pain subgroup.
Frontiers in Nutrition, 2025
NEJM GAIT trial, 2006
Cartilage matrix support
Collagen synthesis cofactor
~5.8 g (unflavoured)
fine-mesh powder, water-dispersible; glucosamine/chondroitin can add slight grittiness at high concentration
stick-pack sachet or shake; less suited to a low-volume RTD given the glucosamine/chondroitin load
