A summary of 12 studies (n=753) on oral fish collagen supplementation, found statistically significant improvements in skin hydration, elasticity and wrinkle depth versus placebo, with no adverse events reported across the pooled studies.
Sodium hyaluronate is included at the exact dose (120 mg/day) used in a 12-week randomized trial that showed measurable improvement in wrinkle score, hydration, and trans epidermal water loss.
Vitamin C is included at a modest margin above the RDA to support the hydroxylation step collagen synthesis depends on.
eSciPub meta-analysis, 2023
MDPI Nutrients, 2021 — oral hyaluronan RCT
NIH ODS — Vitamin C
Parameter
Active base
Hydroxylation cofactor, antioxidant
Skin hydration
Parameter
Hydrolyzed marine collagen
peptide (Type I, <5 kDa)
Sodium ascorbate
(Vitamin C)
Sodium hyaluronate (oral)
